n-BuLi-Catalyzed Amidation Reactions of Aldehydes with 1° Amines
Yujie Su1, Yi Zhang2, Xuehua Zhu(朱雪华)3*, Dan Yuan(袁丹)1*, Yingming Yao(姚英明)1*
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Dushu Lake Campus, Suzhou 215123, People’s Republic of China
2Guangzhou GRG Metrology & Test (WuXi) Co., Ltd., Wuxi 214135, People’s Republic of China
3School of Chemistry and life Science, Suzhou University of Science and Technology, Suzhou, Jiangsu 215009, China
Org. Lett. 2026, 28, 4963–4968
Abstract: A simple and efficient method to achieve the amidation of aldehydes with amines is developed, generating a wide range of secondary amides (41 examples) and tertiary amides (16 examples). This protocol employs a readily available compound n-BuLi as the catalyst and operates under mild, ambient conditions without the need for any additive or external oxidant. Notably, it enables the efficient amidation of primary amines while effectively outcompeting undesired competing condensation reactions.
Article information: https://doi.org/10.1021/acs.orglett.6c01054